Neurologically active peptides
Identifieur interne : 005354 ( Main/Exploration ); précédent : 005353; suivant : 005355Neurologically active peptides
Auteurs : Andre Barbeau [Canada] ; Michel Gonce [Canada] ; Abba J. Kastin [Canada]Source :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1976.
Abstract
This paper reviews recent evidence that a number of small peptides found in the brain are active in the central nervous system and behaviorally. Attention is focused on MSH/ACTH 4–10, α- and β-MSH, and the prophormone β-LPH, as they produce a syndrome of yawning and stretching. Studies with substance P and mainly with MIF-I are also reviewed. It is shown that substance P is an excitatory transmitter or modulator in the dorsal spinal cord and that MIF-I has antiparkinson properties. It is concluded that many polypeptides have direct actions on the central nervous system independent of their neurodocrine properties.
Url:
DOI: 10.1016/0091-3057(76)90346-4
Affiliations:
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